Water → HCID 86692624, compound

Participants

Reaction Steps

Isopropylsulfonyl chloride (72 μl) was added to a suspension of N-[6-(4-cyanopiperidin-4-yl)pyridin-3-yl]-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide (227 mg) described in Reference Example 169 and potassium carbonate (138 mg) in N,N-dimethylformamide (1.7 ml) and stirred at room temperature for six hours. Then, potassium carbonate (276 mg) and isopropylsulfonyl chloride (144 μl) were added and stirred at room temperature for 0.5 hours. Water was added to the reaction solution and the precipitated solid was washed with water, ethanol and ethyl acetate to give the titled compound (151 mg) as a white solid.

Provenance & Evidence