Water → HCID 86692627, compound

Participants

Reaction Steps

Cyclopropanesulfonyl chloride (66 μl) was added to a suspension of N-[6-(4-cyanopiperidine-4-yl)pyridin-3-yl]-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide (227 mg) described in Reference Example 169 and potassium carbonate (207 mg) in N,N-dimethylformamide (1.7 ml), and stirred at room temperature for 5.5 hours. Water was added to the reaction solution and the precipitated solid was purified with silica gel chromatography (chloroform/methanol) to give the titled compound (242 mg) as a white solid.

Provenance & Evidence