Dichloromethane → HCID 86692628, compound

Participants

Reaction Steps

Triethylamine (48 μl) and dimethylsulfamoyl chloride (37 μl) were added to a mixture of N-[6-(4-cyanopiperidin-4-yl)pyridin-3-yl]-5-methyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxamide (150 mg) described in Reference Example 169 and dichloromethane (6.6 ml) and stirred at room temperature for two days. Water was added to the reaction solution, extracted with chloroform, the organic layer was washed with saturated brine, dried over anhydrous sodium sulfate and concentrated in vacuo. The resulting residue was purified with silica gel chromatography (chloroform/methanol) to give the titled compound (135 mg) as a white solid.

Provenance & Evidence