Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 86692640 | HCID 86692640 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 86692641 | HCID 86692641 | 45.7% |
Reaction Steps
A mixture of 12N aqueous solution of sodium hydroxide (0.5 ml), water (2 ml) and ethanol (4 ml) was added to 5-chloro-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxylic acid ethyl ester (120 mg), and stirred at 80° C. for four hours. After the reaction, 1N hydrochoric acid aqueous solution was added under ice-cooling, the precipitated solid was washed with ethyl acetate to give 5-chloro-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazole-4-carboxylic acid (50 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09150555B2 |
|---|
| Source dataset | uspto-grants-2015_10 |
|---|
| ORD ID | ord-8790413071e64171a86c4755a9c6949f |
|---|
| Source note | uspto-grants-2015_10 |
|---|
