Acetyl chloride → HCID 136348417, compound

Participants

Reaction Steps

Acetyl chloride (0.3 mL, 4.2 mmol) was added dropwise to methanol (20 mL), at about 0° C. Tert-butyl 4-[1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]piperidine-1-carboxylate (0.45 g, 1.1 mmol, prepared using General Procedure C from Example #2 step B with 1-Boc-piperidine-4-carboxaldehyde and thioglycolic acid followed by D) was added in portions and the resulting mixture was stirred at rt overnight. Subsequently, the mixture was concentrated in vacuo to afford 1-methyl-4-(4-piperidyl)-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepine dihydrochloride as a yellow solid which was used as such.

Provenance & Evidence