Diisopropylethylamine → HCID 136348421, compound

Participants

Reaction Steps

A mixture of 1-methyl-4-(4-piperidyl)-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepine dihydrochloride (0.10 g, 0.25 mmol, Preparation #4), 2-methylpyridine-3-carboxylic acid (0.0341 g, 0.25 mmol), N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (0.072 g, 0.37 mmol), 1-hydroxybenzotriazole hydrate (0.0505 g, 0.37 mmol) and N,N-diisopropylethylamine (0.22 mL, 1.25 mmol) in DCM (50 mL) was stirred overnight at rt. Then the mixture was concentrated in vacuo and purified by column chromatography (SiO2, DCM/methanol/ammonium hydroxide 92:7.5:0.5) to give (2-methyl-3-pyridyl)-[4-[1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepin-4-yl]-1-piperidyl]methanone (0.080 g, 71%) as an off white solid: LC-MS (Table 1, Method a) Rt=1.50 min; m/z 449 (M+H)+; 1H-NMR (CDCl3, Bruker 400 MHz) 1.17-1.39 (2H, m) 1.44-1.64 (1H, m) 2.08-3.14 (10H, m) 3.22-3.55 (3H, m) 3.74-3.77 (3H, s) 4.58-4.78 (1H, br.d, J=13.0 Hz) 5.06-5.16 (1H, m) 7.05-7.20 (2H, m) 7.36-7.55 (1H, m) 7.62-7.72 (1H, m) 7.89 (1H br.t, J=9.0 Hz) 8.43-8.59 (2H, m).

Provenance & Evidence