HuagongsheHuagongshe Chemistry Print Report · For research reference only
Fmoc-Gly-OH → HCID 131730075, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Fmoc-Gly-OH | HCID 93124 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | N-[(allyloxy)carbonyl]glycine | HCID 11964402 | — |
| Product | HCID 131730075 | HCID 131730075 | — |
Reaction Steps
PEGA 1900 beads (300-500 μm, 0.24 mmol NH2/g) (4 g, 0.96 mmol˜1 eq)) were treated with a 1:1 TBTU coupling mixture of FmocGlyOH (2 eq) and AllocGlyOH (2 eq), NEM (17 eq) and TBTU (3.8 eq). Coupling time 3.5 h. Beads washed 10× with DMF.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09150899B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-61dc27303b10447983f07018f69ac104 |
| Source note | uspto-grants-2015_10 |