HuagongsheHuagongshe Chemistry Print Report · For research reference only
Glycine → Fmoc-Gly-OH
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Glycine | HCID 750 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733207 | — |
| Reactant | HCID 68945927 | HCID 68945927 | — |
| Reactant | HCID 131730075 | HCID 131730075 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Fmoc-Gly-OH | HCID 93124 | — |
Reaction Steps
FmocGly/AllocGly beads were standard Fmoc deprotected with 20% piperidine in DMF leaving the Alloc glycine untouched. Then standard TBTU coupling of the Holmes photolinker (4-(1-aminoethyl-2-methoxy-5-nitrophenoxy)butanoic acid) to the deprotected glycine (1 eq=0.48 mmol). After coupling, the beads were washed with DMF and DCM and lyophilized.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09150899B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-f0342f9f64e64b339a0be7ef5c7c7049 |
| Source note | uspto-grants-2015_10 |