反应详情

温度

125 °C

Lawesson's reagent (458 mg, 1.13 mmol) was added to a toluene solution of 4-cyano-7-fluoro-5-methyl-6-phenyl-1,3-benzoxazole-2-carboxamide (I-196) (304 mg, 1.03 mmol), followed by heating under reflux in an oil bath at 125° C. for 10 minutes. After cooling to room temperature, the reaction liquid was concentrated, and the resulting residue was purified by silica gel column chromatography (eluent, chloroform:ethyl acetate=20:1→10:1) to obtain the entitled compound (134 mg, 41.8%) as a yellow solid.

1. temperatureby heating
2. temperatureAfter cooling to room temperature
3. customthe reaction liquid
4. concentrationwas concentrated
5. customthe resulting residue was purified by silica gel column chromatography (eluent, chloroform:ethyl acetate=20:1→10:1)