m-Chloroperbenzoic acid → HCID 58463270, compound

Participants

Reaction Steps

To a solution of compound 25 (3.64 g, 17.4 mmol) in CH2Cl2 (100 mL) at −40° C., was added 3-chloroperbenzoic acid (3 g, 17.4 mmol) in CH2Cl2 (50 mL) dropwise and the resulting solution was allowed to stir at room temperature overnight. The reaction mixture was washed with aqueous Na2CO3, dried with anhydrous sodium sulfate and evaporated in vacuum. Column chromatography (silica gel, hexane/EtOAc (1/2) yields the pure compound 26 (2.74 g, 70%). 1H NMR (CDCl3): δ 2.82 (3H, s), 7.35 (1H, d), 7.43 (1H, d). MS (EI): calcd, 225.1. found M+, 210.1=product-16).

Provenance & Evidence