2-Aminopropanol → HCID 86099196, compound

HRID 1748966Notes

Reaction equation

HRID 1748966 reaction equation
[C:1]([O:6]CC)(=O)[CH:2]([CH3:4])[OH:3].[NH2:9][CH:10]([CH3:13])[CH2:11][OH:12]>C(O)C>[C:1]([NH:9][CH:10]([CH3:13])[CH2:11][OH:12])(=[O:6])[CH:2]([CH3:4])[OH:3]

Participants

4

Reactant 2

HCID 51262-AminopropanolHCID 7344Ethyl Lactate

Product 1

HCID 86099196HCID 86099196, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
112.5 °C

Procedure

3.7 g ethyl lactate and 2.1 g 2-amino-1-propanol were mixed and subsequently heated to 110-115° C. for 2.5 hours. During the reaction, the ethanol formed was distilled off. After the reaction the excess of ethyl lactate was removed by vacuum distillation (bottom temperature: 150° C., 1 mbar), using a 20 cm vigreux column. 3.9 g of residual N-lactoyl 2-amino-1-propanol (brown viscous liquid) was collected, the purity of which was confirmed by NMR analysis. The yield of the reaction was 95%

Workup

  1. customDuring the reaction
  2. distillationwas distilled off
  3. customAfter the reaction the excess of ethyl lactate
  4. customwas removed by vacuum distillation (bottom temperature: 150° C., 1 mbar)
  5. custom3.9 g of residual N-lactoyl 2-amino-1-propanol (brown viscous liquid) was collected

Sources & evidence

ORD record
ord-2ab2a64603c744e28c7ac545f97b9dad
Source dataset
uspto-grants-2015_10
Patent number
US09155329B2

Reaction notes

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