反应详情

(2,4-Dimethoxy-benzyl)-(2-oxo-1,2,3,4-tetrahydro-pyrido[3,2-d]pyrimidin-6-yl)-carbamic acid tert-butyl ester (Example 20, product from Step 4) (1.09 g, 2.6 mmol, 1.0 equiv) was treated by following methods similar to those described in Example 21, Step 1 except that iodobenzene was used instead of 1-chloro-4-iodo-benzene to afford 420 mg of (2,4-dimethoxy-benzyl)-(2-oxo-1,3-diphenyl-1,2,3,4-tetrahydro-pyrido[3,2-d]pyrimidin-6-yl)-carbamic acid tert-butyl ester (MS: [M+H]+=567) and 358 mg of (2,4-dimethoxy-benzyl)-(2-oxo-1-phenyl-1,2,3,4-tetrahydro-pyrido[3,2-d]pyrimidin-6-yl)-carbamic acid tert-butyl ester. MS: [M+H]+=491.