4-Chloro-1-fluoro-2-iodobenzene → HCID 70981310, compound

HRID 1749105Notes

Reaction equation

HRID 1749105 reaction equation
[C:1]([O:5][C:6](=[O:36])[N:7]([CH2:25][C:26]1[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][C:27]=1[O:34][CH3:35])[C:8]1[CH:9]=[CH:10][C:11]2[N:12]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:13](=[O:18])[NH:14][CH2:15][C:16]=2[N:17]=1)([CH3:4])([CH3:3])[CH3:2].[Cl:37][C:38]1[CH:43]=[CH:42][C:41]([F:44])=[C:40](I)[CH:39]=1>>[C:1]([O:5][C:6](=[O:36])[N:7]([C:8]1[CH:9]=[CH:10][C:11]2[N:12]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[C:13](=[O:18])[N:14]([C:42]3[CH:43]=[C:38]([Cl:37])[CH:39]=[CH:40][C:41]=3[F:44])[CH2:15][C:16]=2[N:17]=1)[CH2:25][C:26]1[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][C:27]=1[O:34][CH3:35])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 27736524-Chloro-1-fluoro-2-iodobenzeneHCID 70979993HCID 70979993, compound

Product 1

HCID 70981310HCID 70981310, compound

Procedure

(2,4-Dimethoxy-benzyl)-(2-oxo-1-phenyl-1,2,3,4-tetrahydro-pyrido[3,2-d]pyrimidin-6-yl)-carbamic acid tert-butyl ester (380 mg, 0.77 mmol) was treated according to the procedure of Example 21, Step 1, using 4-chloro-1-fluoro-2-iodo-benzene instead of 1-chloro-4-iodo-benzene to afford [3-(5-chloro-2-fluoro-phenyl)-2-oxo-1-phenyl-1,2,3,4-tetrahydro-pyrido[3,2-d]pyrimidin-6-yl]-(2,4-dimethoxy-benzyl)-carbamic acid tert-butyl ester (233 mg). MS: [M+H]+=619.

Sources & evidence

ORD record
ord-6e405128241443d9a4dd2d67a03ab310
Source dataset
uspto-grants-2015_10
Patent number
US09155743B2

Reaction notes

Loading…