HCID 76183230, compound → Methyl 4,4-difluoro-3-oxobutanoate

HRID 1749116Notes

Reaction equation

HRID 1749116 reaction equation
[F:1][CH:2]([F:10])[C:3]([OH:9])=[CH:4][C:5]([O:7][CH3:8])=[O:6]>CO>[F:1][CH:2]([F:10])[C:3](=[O:9])[CH2:4][C:5]([O:7][CH3:8])=[O:6]

Participants

3

Reactant 1

HCID 76183230HCID 76183230, compound

Product 1

HCID 13179258Methyl 4,4-difluoro-3-oxobutanoate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The procedure of Example 4 was repeated using methanol instead of ethanol. After distillation the methyl ester was obtained as a colorless liquid. According to the 1H NMR data the product was a tautomeric mixture of ca. 60% keto form and ca. 40% enol form (methyl 4,4-difluoro-3-hydroxybut-2-enoate).

Workup

  1. distillationAfter distillation the methyl ester
  2. customwas obtained as a colorless liquid

Sources & evidence

ORD record
ord-5ca2312bf468435da2dfd0d085194da8
Source dataset
uspto-grants-2015_10
Patent number
US09156771B2

Reaction notes

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