HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-chloro-1-(pyridin-3-yl)-1H-pyrazole-4-carboxylic acid → 3-(3-chloro-1H-pyrazol-1-yl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-chloro-1-(pyridin-3-yl)-1H-pyrazole-4-carboxylic acid | HCID 86705825 | — |
| Catalyst | Copper oxide | HCID 14829 | — |
| Product | 3-(3-chloro-1H-pyrazol-1-yl)pyridine | HCID 67499540 | — |
Reaction Steps
decarboxylating 3-chloro-1-(pyridin-3-yl)-1H-pyrazole-4-carboxylic acid (4) with copper oxide in a polar aprotic solvent at a temperature of about 80° C. to about 180° C. to provide 3-(3-chloro-1H-pyrazol-1-yl)pyridine (5b).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09156813B1 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-1a2883beb01d4292a2362586d81e7386 |
| Source note | uspto-grants-2015_10 |