HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1749206Generated: November 1, 2026
Water → 3-chloro-1-(pyridin-3-yl)-1H-pyrazole-4-carboxylic acid
https://huagongshe.com/reaction/1749206
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 3-(3-chloro-4-methyl-1H-pyrazol-1-yl)pyridine | HCID 21624435 | — |
| Reactant | Sodium Permanganate | HCID 23673458 | — |
| Solvent | tert-Butanol | HCID 6386 | — |
| Product | 3-chloro-1-(pyridin-3-yl)-1H-pyrazole-4-carboxylic acid | HCID 86705825 | — |
Reaction Steps
In another embodiment, 3-(3-chloro-4-methyl-1H-pyrazol-1-yl)pyridine (3) is further oxidized by sodium permanganate in water and tert-butanol and heated at about 80° C. The 3-chloro-1-(pyridin-3-yl)-1H-pyrazole-4-carboxylic acid (4) can be isolated and purified by standard techniques.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09156813B1 |
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| Source dataset | uspto-grants-2015_10 |
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| ORD ID | ord-be553582a9af4426a83f30a45ebb05d8 |
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| Source note | uspto-grants-2015_10 |
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