反应详情

温度

25 °C

Compound 62 (93 mg) and zinc (147 mg) were suspended in acetic acid (2 mL) and the suspension was stirred at room temperature (20 to 30° C.) for 3 hours. Subsequently, the reaction mixture was filtered and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (ethyl acetate:hexane=5:1 to 3:1) to give 25.4 mg (29% yield) of the desired product as a pale yellow amorphous.

1. filtrationSubsequently, the reaction mixture was filtered
2. concentrationthe filtrate was concentrated under reduced pressure
3. customThe resulting residue was purified by silica gel column chromatography (ethyl acetate:hexane=5:1 to 3:1)