HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3,5-trimethyl-1H-pyrazol-4-amine → 4-Bromo-2,6-Dichloro-N-(1,3,5-Trimethyl-1h-Pyrazol-4-Yl)benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3,5-trimethyl-1H-pyrazol-4-amine | HCID 161603 | — |
| Reactant | 4-Bromo-2,6-dichlorobenzene-1-sulfonyl chloride | HCID 2737466 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 4-Bromo-2,6-Dichloro-N-(1,3,5-Trimethyl-1h-Pyrazol-4-Yl)benzenesulfonamide | HCID 46188877 | 89% |
Reaction Steps
Prepared from 4-bromo-2,6-dichlorobenzenesulfonyl chloride (5.0 g, 15.4 mmol) and 4-amino-1,3,5-trimethyl-1H-pyrazole (1.93 g, 15.4 mmol) in pyridine (35 ml) according to the method of intermediate 1, to give the title compound as an orange solid (5.64 g, 13.7 mmol, 89%). δH (D-6 DMSO, 300K) 9.75 (1H, s), 8.00 (2H, s), 3.57 (3H, s), 1.93 (3H, s), 1.72 (3H, s). m/z (ES+, 70V) 413.9 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09156811B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-f265d02a5e504edfaefcbb6ab55992bf |
| Source note | uspto-grants-2015_10 |