1,3,5-trimethyl-1H-pyrazol-4-amine → HCID 58561079, compound

Participants

Reaction Steps

Prepared from 2,5-difluoro-4-bromobenzenesulfonyl chloride (2 g, 6.9 mmol) and 4-amino-1,3,5-trimethyl-1H-pyrazole (858 mg, 6.9 mmol) in pyridine (30 ml) according to the method of intermediate 1, to give the title compound as a pale yellow solid (1.9 g, 5.0 mmol, 73%). δH (D-6 DMSO, 300K) 9.77 (1H, s), 8.12 (1H, dd, J=5.5 Hz 9.0 Hz), 7.55 (1H, dd J 6.Hz 7.5 Hz), 3.58 (3H, s), 1.92 (3H, s), 1.74 (3H, s). m/z (ES+, 70V) 380.0 (MH+).

Provenance & Evidence