HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,3,5-trimethyl-1H-pyrazol-4-amine → HCID 7677840, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,3,5-trimethyl-1H-pyrazol-4-amine | HCID 161603 | — |
| Reactant | 2-Chloro-5-pyridinesulfonyl chloride | HCID 2792792 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 7677840 | HCID 7677840 | 75.3% |
Reaction Steps
Prepared from 6-chloropyridine-3-sulfonyl chloride (4.8 g, 22.7 mmol) and 4-amino-1,3,5-trimethyl-1H-pyrazole (2.84 g, 22.7 mmol) in pyridine (35 ml) according to the method of intermediate 1, to give the title compound as a white solid (5.13 g, 17.1 mmol, 75%). δH (D-6 DMSO, 300K) 9.51 (1H, s), 8.59 (1H, d J 2.3 Hz), 8.03 (1H, dd J 7.6 Hz 2.3 Hz), 7.77 (1H, d J 7.6 Hz), 3.58 (3H, s), 1.84 (3H, s), 1.63 (3H, s). m/z (ES+, 70V) 301.1 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09156811B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-486bcc516d9e4aa699665e62633f550e |
| Source note | uspto-grants-2015_10 |