4-Bromo-2,6-dichlorobenzene-1-sulfonyl chloride → HCID 47183721, compound

HRID 1749363Notes

Reaction equation

HRID 1749363 reaction equation
[Br:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([S:9](Cl)(=[O:11])=[O:10])=[C:4]([Cl:13])[CH:3]=1.[NH2:14][C:15]1[CH:16]=[N:17][N:18]([CH3:20])[CH:19]=1>N1C=CC=CC=1>[Br:1][C:2]1[CH:7]=[C:6]([Cl:8])[C:5]([S:9]([NH:14][C:15]2[CH:16]=[N:17][N:18]([CH3:20])[CH:19]=2)(=[O:11])=[O:10])=[C:4]([Cl:13])[CH:3]=1

Participants

4

Reactant 2

HCID 27374664-Bromo-2,6-dichlorobenzene-1-sulfonyl chlorideHCID 47709901-methyl-1H-pyrazol-4-amine

Product 1

HCID 47183721HCID 47183721, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Prepared from 4-bromo-2,6-dichlorobenzenesulfonyl chloride (500 mg, 1.54 mmol) and 4-amino-1-methyl-1H-pyrazole (206 mg, 1.54 mmol) in pyridine (3 ml) according to the method of intermediate 1, to give the title compound as a white solid (496 mg, 1.29 mmol, 84%). δH (D-6 DMSO, 300K) 7.64 (2H, s), 7.45 (1H, s), 7.18 (1H, s), 7.01 (1H, s), 3.85 (3H, s). m/z (ES+, 70V) 385.9 (MH+).

Sources & evidence

ORD record
ord-fd6b7fe5e11a4dca8a1722fec734b6fe
Source dataset
uspto-grants-2015_10
Patent number
US09156811B2

Reaction notes

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