Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Chloro-2-(methylsulfanyl)pyrimidine-5-carbonitrile | HCID 13114183 | — |
| Reactant | 3-ethoxy-2,2-dimethylcyclobutan-1-amine | HCID 53619938 | — |
| Solvent | Tert-butyl alcohol 1,2-dichloroethane | HCID 21868497 | — |
| Product | HCID 118162129 | HCID 118162129 | 100% |
Reaction Steps
A solution of 3-ethoxy-2,2-dimethylcyclobutanamine (1.0 equiv.) and 4-chloro-2-(methylthio)pyrimidine-5-carbonitrile (1.1 equiv.) in tert-butanol/1,2-dichloroethane (0.5 M) was treated with potassium carbonate powder (3.0 equiv.). The resulting reaction mixture was then heated at 70° C. under nitrogen for 3 h. After cooling, ethyl acetate was added and the mixture was vigorously stirred. The solid was removed by vacuum-filtration. The filtrate was concentrated and further dried to give (100% yield) of waxy, yellow solid, which was used in the next step without further purification. MS (ESI) m/z 293.0 [M+1]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09156798B2 |
|---|
| Source dataset | uspto-grants-2015_10 |
|---|
| ORD ID | ord-faf4807f230e43769abb6eaa025388a4 |
|---|
| Source note | uspto-grants-2015_10 |
|---|
