HCID 90299189, compound → HCID 118162229, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-(4-bromo-3-(trifluoromethoxy)phenyl)acetonitrile (800 mg, 2.86 mmol) in THF (40 mL) was added a solution of borane dimethyl sulfide complex in THF (2 M, 2.15 mL, 4.3 mmol) at 0° C. The resulting solution was heated at 75° C. for 2 h under nitrogen atmosphere. The reaction was quenched with MeOH (10 mL) at 0° C. and concentrated under vacuum to afford the crude title product (720 mg, 2.54 mmol). MS (ESI) m/z 283.9 M+, 291.1 [M+2]+.

Provenance & Evidence