反应详情

To a solution of 2-(3-chloro-2-(trifluoromethyl)phenyl)acetonitrile (0.10 g, 3.03 mmol) in MeOH (5 mL) was added Raney-nickel (100 mg). The mixture was degassed under vacuum for 10 min, and then hydrogenated under a fully-inflated balloon at room temperature overnight. The mixture was filtered through a pad of celite and the cake was washed with MeOH (10 mL). The filtrate was concentrated under vacuum to give the crude product (100 mg). MS (ESI) m/z 224.1 [M+H]+.

1. customThe mixture was degassed under vacuum for 10 min
2. filtrationThe mixture was filtered through a pad of celite
3. washthe cake was washed with MeOH (10 mL)
4. concentrationThe filtrate was concentrated under vacuum