反应详情

N-Phenethylacetamide (4.50 g, 27.6 mmol) was added to sulfurochloridic acid (30 mL) slowly at 0-5° C. The resulting reaction mixture was stirred at room temperature for 2 h. The reaction mixture was poured into ice-water and stirred for 10 min. The mixture was extracted with DCM. The combined organic layers were washed with brine, dried over anhydrous sodium sulfate and concentrated to afford the title compound as a brown solid (3.30 g, 12.64 mmol, 45% yield). MS (ESI) m/z 262.1 [M+H]+.

1. customThe resulting reaction mixture
2. stirringstirred for 10 min
3. extractionThe mixture was extracted with DCM
4. washThe combined organic layers were washed with brine
5. dry with materialdried over anhydrous sodium sulfate
6. concentrationconcentrated