Formaldehyde → HCID 71278788, compound

Participants

Reaction Conditions

Reaction Steps

A solution of (Z)-2-[(1H-indol-3-yl)methylene]-6-hydroxybenzofuran-3(2H)-one (0.051 g, 0.19 mmol) obtained in Example A1, Step 1 in ethanol (2.0 mL) was added with 1-(2-methoxyethyl)piperazine (0.036 g, 0.25 mmol), and 37% aqueous formaldehyde (0.021 g, 0.25 mmol), and the mixture was stirred overnight at 80° C. in a sealed tube. The solvent was evaporated under reduced pressure, and then the residue was subjected to silica gel column chromatography (aminopropyl silica was used, eluted with chloroform/methanol (90:10)) to obtain (Z)-2-[(1H-indol-3-yl)methylene]-6-hydroxy-7-{[4-(2-methoxyethyl)piperazin-1-yl]methyl}benzofuran-3(2H)-one (0.027 g, 33%).

Provenance & Evidence