Formaldehyde → HCID 71278620, compound

Participants

Reaction Conditions

Reaction Steps

A solution of (Z)-2-[(1H-indol-3-yl)methylene]-6-hydroxybenzofuran-3(2H)-one (0.030 g, 0.11 mmol) obtained in Example A1, Step 1 in ethanol (2.0 mL) was added with N,N,N′-trimethylpropane-1,3-diamine (0.015 g, 0.13 mmol), and 37% aqueous formaldehyde (0.011 g, 0.13 mmol), and the mixture was stirred overnight at 80° C. in a sealed tube. The solvent was evaporated under reduced pressure, and then the residue was subjected to silica gel column chromatography (aminopropyl silica was used, eluted with chloroform/methanol (90:10)) to obtain (Z)-2-[(1H-indol-3-yl)methylene]-7-({[3-(dimethylamino)propyl](methyl)amino}methyl)-6-hydroxybenzofuran-3(2H)-one (0.024 g, 54%).

Provenance & Evidence