Formaldehyde → HCID 86681910, compound

Participants

Reaction Conditions

Reaction Steps

A solution of (Z)-2-[(1H-indol-3-yl)methylene]-6-hydroxybenzofuran-3(2H)-one (0.10 g, 0.36 mmol) obtained in Example A1, Step 1 in ethanol (2.0 mL) was added with ethyl nipecotate (0.068 g, 0.43 mmol), and 37% aqueous formaldehyde (0.036 g, 0.46 mmol), and the mixture was stirred overnight at 80° C. in a sealed tube. The solvent was evaporated under reduced pressure, and then the residue was subjected to silica gel column chromatography (aminopropyl silica was used, eluted with chloroform/methanol (90:10)) to obtain ethyl (Z)-1-({2-[(1H-indol-3-yl)methylene]-6-hydroxy-3-oxo-2,3-dihydrobenzofuran-7-yl}methyl)piperidine-3-carboxylate (0.056 g, 35%).

Provenance & Evidence