Formaldehyde → HCID 60155788, compound

Participants

Reaction Conditions

Reaction Steps

A solution of (Z)-2-[(1H-indol-3-yl)methylene]-6-hydroxybenzofuran-3(2H)-one (0.20 g, 0.72 mmol) obtained in Example A1, Step 1 in ethanol (10 mL) was added with 1-tert-butoxycarbonylpiperazine (0.16 g, 0.87 mmol), and 37% aqueous formaldehyde (0.068 g, 0.87 mmol), and the mixture was stirred overnight at 80° C. in a sealed tube. The solvent was evaporated under reduced pressure, and then the residue was subjected to silica gel column chromatography (eluted with chloroform/methanol (90:10)) to obtain tert-butyl (Z)-4-({2-[(1H-indol-3-yl)methylene]-6-hydroxy-3-oxo-2,3-dihydrobenzofuran-7-yl}methyl)piperazine-1-carboxylate (0.22 g, 63%).

Provenance & Evidence