Benzoyl Peroxide → HCID 86681918, compound

Participants

Reaction Steps

The synthesis was performed with reference to the known literature (Bioconjugate Chemistry, Vol. 18, p. 275, 2007). A solution of 5-methoxy-7-methylbenzofuran-3(2H)-one (0.25 g, 1.4 mmol) in carbon tetrachloride (15 mL) was successively added with N-bromosuccinimide (0.27 g, 1.5 mmol), and benzoyl peroxide (0.025 g, 0.070 mmol), and the mixture was refluxed for 2 hours by heating. The solid in the reaction mixture was removed by filtration, and the solvent was evaporated under reduced pressure. The residue was subjected to silica gel column chromatography (eluted with hexane/ethyl acetate (75:25)) to obtain 7-(bromomethyl)-5-methoxybenzofuran-3(2H)-one (0.040 g, 11%).

Provenance & Evidence