Acetic Anhydride → N-(1H-Indol-5-ylmethyl)acetamide

Participants

Reaction Steps

The synthesis was performed with reference to the known literature (International Patent Publication WO2000/75139). 5-Aminomethyl-1H-indole (0.50 g, 3.4 mmol) was added with acetic anhydride (2.0 mL), and the mixture was stirred at room temperature for 3 hours. The mixture was azeotroped twice with toluene under reduced pressure, and the residual solid was washed with ethyl acetate to obtain N-[(1H-indol-5-yl)methyl]acetamide (0.62 g, 96%).

Provenance & Evidence