HCID 60155788, compound → tert-butyl 4-({2-[(1H-indol-3-yl)methyl]-6-hydroxy-3-oxo-2,3-dihydrobenzofuran-7-yl}methyl)piperazine-1-carboxylate

Participants

Reaction Steps

A solution of tert-butyl (Z)-4-({2-[(1H-indol-3-yl)methylene]-6-hydroxy-3-oxo-2,3-dihydrobenzofuran-7-yl}methyl)piperazine-1-carboxylate (0.030 g, 0.063 mmol) obtained in Example A11, Step 1 in ethanol (2.0 mL) was added with 5% palladium/carbon (wetted with 50% water, 0.027 g) under an argon atmosphere, and then the inside of the reaction vessel was replaced with hydrogen. The reaction mixture was stirred at room temperature for 4 hours, and then filtered through Celite, and the solvent was evaporated under reduced pressure to obtain tert-butyl 4-({2-[(1H-indol-3-yl)methyl]-6-hydroxy-3-oxo-2,3-dihydrobenzofuran-7-yl}methyl)piperazine-1-carboxylate (0.028 g, 93%).

Provenance & Evidence