Hydrochloric Acid → HCID 86681960, compound

Participants

Reaction Steps

A solution of tert-butyl (E)-4-({2-[(1H-indol-3-yl)methylene]-5-hydroxy-1-oxo-2,3-dihydro-1H-inden-4-yl}methyl)piperazine-1-carboxylate (0.030 g, 0.063 mmol) in methylene chloride (2.0 mL) was added with a 4 M solution of hydrogen chloride in 1,4-dioxane (2.0 mL), and then the mixture was stirred at room temperature for 1 hour. The mixture was azeotroped twice with toluene under reduced pressure, and the residual solid was suspended in methylene chloride and thereby washed to obtain (E)-2-[(1H-indol-3-yl)-methylene]-5-hydroxy-4-(piperazin-1-ylmethyl)-2,3-dihydro-1H-inden-1-one dihydrochloride (0.024 g, 85%).

Provenance & Evidence