Formaldehyde → HCID 71278947, compound

Participants

Reaction Steps

A solution of 6-hydroxybenzofuran-3(2H)-one (2.00 g, 13.3 mmol) in ethanol (25 mL) was added with N-methylpiperazine (1.33 g, 13.3 mmol), and 37% aqueous formaldehyde (1.08 g, 13.3 mmol) at room temperature. The mixture was stirred overnight at room temperature, and then subjected to suction filtration, and the filtrate was concentrated. The residue was purified by silica gel column chromatography (chloroform/methanol) to obtain 6-hydroxy-7-[(4-methylpiperazin-1-yl)methyl]benzofuran-3(2H)-one (1.87 g, 54%).

Provenance & Evidence