Piperidine → HCID 86681971, compound

Participants

Reaction Steps

tert-Butyl 4-[(6-hydroxy-3-oxo-2,3-dihydrobenzofuran-7-yl)methyl]piperazine-1-carboxylate (0.100 g, 0.287 mmol) obtained in Example A16, Step 1 and 1-(4-chlorophenylsulfonyl)-1H-indole-3-carboxaldehyde (0.0918 g, 0.287 mmol) were stirred overnight at room temperature in methanol (1.2 mL) in the presence of piperidine (0.00244 g, 0.0287 mmol). The reaction mixture was further added with methanol (1 mL), and the solid was suspended in methanol and thereby washed to obtain tert-butyl (Z)-4-[(2-{[1-(4-chlorophenylsulfonyl)-1H-indol-3-yl]methylene}-6-hydroxy-3-oxo-2,3-dihydrobenzofuran-7-yl)methyl]piperazine-1-carboxylate (0.161 g, 86%).

Provenance & Evidence