Hydrochloric Acid → HCID 86681991, compound

Participants

Reaction Steps

A solution of tert-butyl (Z)-4-({2-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-6-hydroxy-3-oxo-2,3-dihydrobenzofuran-7-yl}methyl)piperazine-1-carboxylate (0.0788 g, 0.165 mmol) in methylene chloride (2 mL) was added with a 4 M solution of hydrochloric acid in dioxane (2 mL), and the mixture was stirred at room temperature for 2 hours. The reaction mixture was filtered, and the resulting solid was washed with acetonitrile to obtain the objective (Z)-2-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-6-hydroxy-7-(piperazin-1-ylmethyl)benzofuran-3(2H)-one trihydrochloride (0.0518 g, 64%).

Provenance & Evidence