Formaldehyde → HCID 71278572, compound

Participants

Reaction Steps

A solution of 6-hydroxybenzofuran-3(2H)-one (0.750 g, 5.00 mmol) in ethanol (5 mL) was added with 2-oxopiperazine (0.500 g, 5.00 mmol), and 37% aqueous formaldehyde (0.406 g, 5.00 mmol) at room temperature. The mixture was stirred overnight at room temperature, and then added with 37% aqueous formaldehyde (0.406 g, 5.00 mmol) at room temperature, and the mixture was refluxed for 4 hours by heating. The reaction mixture was cooled to room temperature, and then subjected to suction filtration to obtain 4-[(6-hydroxy-3-oxo-2,3-dihydrobenzofuran-7-yl)methyl]piperazin-2-one (0.631 g, 48%) as a white solid.

Provenance & Evidence