HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 5-bromo-1H-pyrrolo(2,3-b)pyridine-3-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Hexamethylenetetramine | HCID 4101 | — |
| Reactant | 5-bromo-1H-pyrrolo[2,3-b]pyridine | HCID 10307932 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5-bromo-1H-pyrrolo(2,3-b)pyridine-3-carbaldehyde | HCID 24729605 | 62% |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
5-Bromo-1H-pyrrolo[2,3-b]pyridine (0.087 g, 0.44 mmol) was successively added with acetic acid (0.2 mL), water (0.4 mL), and hexamethylenetetramine (0.087 g, 0.62 mmol), and then the mixture was stirred overnight at 120° C. in a sealed tube. The reaction mixture was added with water, and then the precipitated solid was collected by filtration to obtain 5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxaldehyde (0.061 g, 62%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09156827B2 |
| Source dataset | uspto-grants-2015_10 |
| ORD ID | ord-d28835fff69b43e590c63f053692810e |
| Source note | uspto-grants-2015_10 |