Formaldehyde → HCID 60155785, compound

Participants

Reaction Steps

A solution of 6-hydroxybenzofuran-3(2H)-one (0.150 g, 1.00 mmol) in ethanol (1 mL) was added with tert-butyl 1,4-diazepane-1-carboxylate (0.200 g, 1.00 mmol) and paraformaldehyde (0.0300 g, 1.00 mmol) at room temperature, and the mixture was refluxed for 3 hours by heating. The reaction mixture was concentrated, and the resulting residue was purified by silica gel column chromatography (hexane/ethyl acetate) to obtain tert-butyl 4-[(6-hydroxy-3-oxo-2,3-dihydrobenzofuran-7-yl)methyl]-1,4-diazepane-1-carboxylate (0.0583 g, 16%).

Provenance & Evidence