反应详情

A solution of 7-methylbenzofuran-3(2H)-one (0.759 g, 5.12 mol) in carbon tetrachloride (50 mL) was added with N-bromosuccinimide (1.00 g, 5.63 mmol) and benzoyl peroxide (0.0830 g, 0.256 mmol), and the mixture was refluxed for 4 hours by heating. The reaction mixture was cooled to room temperature, and then filtered, and the resulting filtrate was concentrated. The residue was purified by silica gel column chromatography (hexane/ethyl acetate) to obtain 7-bromomethylbenzofuran-3(2H)-one (0.573 g, 49%).

1. temperaturethe mixture was refluxed for 4 hours
2. temperatureby heating
3. filtrationfiltered
4. concentrationthe resulting filtrate was concentrated
5. customThe residue was purified by silica gel column chromatography (hexane/ethyl acetate)