HCID 178520041, compound → HCID 178520040, compound

Participants

Reaction Steps

A solution of [5-(trifluoromethoxy)-1H-indazol-3-yl]methanol (0.109 g, 0.470 mmol) in ethyl acetate (2 mL) was added with manganese dioxide (0.409 g, 4.70 mmol), and the reaction mixture was stirred overnight at room temperature. The reaction mixture was filtered through Celite, then the filtrate was concentrated, and the resulting residue was purified by silica gel column chromatography (chloroform/methanol) to obtain the objective 5-(trifluoromethoxy)-1H-indazole-3-carbaldehyde (0.0710 g, 65%).

Provenance & Evidence