Piperidine → HCID 178452317, compound

Participants

Reaction Conditions

Reaction Steps

A solution of tert-butyl 4-[(5-chloro-6-hydroxy-3-oxo-2,3-dihydrobenzofuran-7-yl)methyl]piperazine-1-carboxylate (0.100 g, 0.261 mmol) in methanol (1 mL) was added with indazole-3-carbaldehyde (0.0381 g, 0.261 mmol), and piperidine (0.00222 g, 0.0261 mmol) at room temperature, and the mixture was stirred at 60° C. for 3 hours. The reaction mixture was cooled to room temperature, then added with methanol (4 mL), suspended in methanol and thereby washed, and the solid was collected by filtration to obtain tert-butyl (Z)-4-({2-[(1H-indazol-3-yl)methylene]-5-chloro-6-hydroxy-3-oxo-2,3-dihydrobenzofuran-7-yl}methyl)piperazine-1-carboxylate (0.0890 g, 66%).

Provenance & Evidence