Trifluoroacetic acid → HCID 178487225, compound

Participants

Reaction Steps

A solution of tert-butyl (Z)-4-({2-[(1H-indazol-3-yl)methylene]-6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-yl}methyl)piperazine-1-carboxylate (0.188 g, 0.383 mmol) in methylene chloride (6 mL) was added with trifluoroacetic acid (6 mL) at room temperature, and the mixture was stirred overnight. The solvent was evaporated, then the residue was dissolved in methanol (8 mL), the solution was added with a 5% solution of hydrochloric acid in methanol (2 mL), and the mixture was stirred at room temperature for 2 hours. The precipitated solid was collected by filtration, and added to saturated aqueous sodium hydrogencarbonate, and the mixture was extracted three times with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, and then the solvent was evaporated to obtain the objective (Z)-2-[(1H-indazol-3-yl)methylene]-6-methoxy-7-(piperazin-1-ylmethyl)benzofuran-3(2H)-one (0.0130 g, 8%).

Provenance & Evidence