Trifluoroacetic acid → HCID 178487226, compound

Participants

Reaction Steps

A solution of tert-butyl (Z)-4-({2-[(5-chloro-1H-indazol-3-yl)methylene]-6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-yl}methyl)piperazine-1-carboxylate (0.0330 g, 0.0629 mmol) in methylene chloride (2 mL) was added with trifluoroacetic acid (2 mL) at room temperature, and the mixture was stirred overnight. The reaction mixture was concentrated, then the residue was added with saturated aqueous sodium hydrogencarbonate (10 mL), and the mixture was extracted three times with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate, and then the solvent was evaporated to obtain (Z)-2-[(5-chloro-1H-indazol-3-yl)methylene]-6-methoxy-7-(piperazin-1-ylmethyl)benzofuran-3(2H)-one (0.0120 g, 44%).

Provenance & Evidence