Trifluoroacetic acid → HCID 178487224, compound

Participants

Reaction Steps

A solution of tert-butyl (Z)-4-({2-[(5-bromo-1H-indazol-3-yl)methylene]-6-methoxy-3-oxo-2,3-dihydrobenzofuran-7-yl}methyl)piperazine-1-carboxylate (0.160 g, 0.281 mmol) in methylene chloride (4 mL) was added with trifluoroacetic acid (4 mL) at room temperature, and the mixture was stirred overnight. The reaction mixture was concentrated, and then added with water (10 mL) and saturated aqueous sodium hydrogencarbonate (10 mL), and the mixture was stirred at room temperature for 1 hour. The reaction mixture was filtered, and then the resulting solid was washed with water to obtain the objective (Z)-2-[(5-bromo-1H-indazol-3-yl)methylene]-6-methoxy-7-(piperazin-1-ylmethyl)benzofuran-3(2H)-one (0.0860 g, 65%).

Provenance & Evidence