Trifluoroacetic acid → HCID 178458175, compound

Participants

Reaction Steps

A solution of tert-butyl (Z)-4-({2-[(1H-indazol-3-yl)methylene]-3-oxo-6-propoxy-2,3-dihydrobenzofuran-7-yl}methyl)piperazine-1-carboxylate (0.0210 g, 0.0405 mmol) in methylene chloride (1 mL) was added with trifluoroacetic acid (1 mL) at room temperature, and the mixture was stirred overnight. The reaction mixture was added with saturated aqueous sodium hydrogencarbonate, thereby made basic, and then extracted three times with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate, and then the solvent was evaporated to obtain the objective (Z)-2-[(1H-indazol-3-yl)methylene]-7-(piperazin-1-ylmethyl)-6-propoxybenzofuran-3(2H)-one (0.0160 g, 94%).

Provenance & Evidence