Water → HCID 178458174, compound

Participants

Reaction Steps

A solution of tert-butyl (Z)-4-({2-[(1H-indazol-3-yl)methylene]-6-isopropoxy-3-oxo-2,3-dihydrobenzofuran-7-yl}methyl)piperazine-1-carboxylate (0.0740 g, 0.143 mmol) in methylene chloride (2 mL) was added with trifluoroacetic acid (2 mL) at room temperature, and the mixture was stirred overnight. The reaction mixture was added with water (6 mL) and saturated aqueous sodium hydrogencarbonate (6 mL), and thereby made basic, and then the mixture was stirred at room temperature for 1 hour. The reaction mixture was subjected to suction filtration, and the resulting solid was washed with water to obtain the objective (Z)-2-[(1H-indazol-3-yl)methylene]-6-isopropoxy-7-(piperazin-1-ylmethyl)benzofuran-3(2H)-one (0.0301 g, 50%).

Provenance & Evidence