Trifluoroacetic acid → HCID 178515794, compound

Participants

Reaction Steps

A solution of tert-butyl (Z)-4-({2-[(1H-indazol-3-yl)methylene]-3-oxo-6-phenethoxy-2,3-dihydrobenzofuran-7-yl}methyl)piperazine-1-carboxylate (0.0730 g, 0.126 mmol) in methylene chloride (3 mL) was added with trifluoroacetic acid (3 mL) at room temperature, and the mixture was stirred overnight. The reaction mixture was concentrated, added with methanol (8 mL) and a 5% solution of hydrogen chloride in methanol (2 mL), and thereby made basic, and then the mixture was stirred at room temperature for 2 hours. The reaction mixture was concentrated, and then the residue was suspended in acetonitrile and thereby washed to obtain an orange solid. This solid was suspended in water (4 mL) and saturated aqueous sodium hydrogencarbonate (4 mL), and the suspension was stirred for 1 hour. The reaction mixture was filtered, and then the resulting solid was washed with water to obtain the objective (Z)-2-[(1H-indazol-3-yl)methylene]-6-phenethoxy-7-(piperazin-1-ylmethyl)benzofuran-3(2H)-one (0.0211 g, 34%).

Provenance & Evidence