Trifluoroacetic acid → HCID 178515795, compound

Participants

Reaction Steps

A solution of tert-butyl (Z)-4-({2-[(1H-indazol-3-yl)methylene]-3-oxo-6-(2-phenoxyethoxy)-2,3-dihydrobenzofuran-7-yl}methyl)piperazine-1-carboxylate (0.0380 g, 0.0637 mmol) in methylene chloride (2 mL) was added with trifluoroacetic acid (2 mL) at room temperature, and the mixture was stirred overnight. The reaction mixture was concentrated, and added with water (4 mL) and saturated aqueous sodium hydrogencarbonate (4 mL), and the mixture was stirred for 1 hour. The reaction mixture was filtered, and then the resulting solid was washed with water to obtain the objective (Z)-2-((1H-indazol-3-yl)methylene)-6-(2-phenoxyethoxy)-7-(piperazin-1-ylmethyl)benzofuran-3(2H)-one (0.0280 g, 88%).

Provenance & Evidence