tert-Butyl piperazine-1-carboxylate → HCID 71278536, compound

Participants

Reaction Steps

A solution of 6-hydroxy-3-oxo-2,3-dihydrobenzofuran-7-carboxylic acid (0.060 g, 0.31 mmol) in methylene chloride (2.0 mL) was successively added with 1-hydroxybenzotriazole monohydrate (0.008 g, 0.052 mmol), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (0.086 g, 0.45 mmol), and N-Boc-piperazine (0.067 g, 0.36 mmol), and the mixture was stirred at room temperature for 14 hours. The reaction mixture was added with water, the mixture was extracted with ethyl acetate, and the organic layer was washed successively with water and saturated brine, and then dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was subjected to silica gel column chromatography (eluted with chloroform/methanol (99:1→90:10)) to obtain tert-butyl 4-(6-hydroxy-3-oxo-2,3-dihydrobenzofuran-7-carbonyl)piperazine-1-carboxylate (0.072 g, 66%).

Provenance & Evidence